Doxorubicin is a chemotherapy drug used to treat many different forms of cancer. It works by interfering with the function of DNA in rapidly dividing cells. Cancer cells divide particularly rapidly, and doxorubicin can cause them to die. However, certain types of normal body cells also divide rapidly; doxorubicin damages them as well. This leads to a variety of possible side effects, including hair loss, digestive problems, reduced immunity, excessive bruising or bleeding, anemia, mouth sores and male infertility. Doxorubicin can also damage the heart and kidneys, apparently by interfering with the action of the mitochondria in heart cells. (Mitochondria are the energy-producing subunits of cells.)
It is hypothesized that many of the side effects of doxorubicin occur through the production of free radicals, dangerous substances that can harm many cells. Antioxidants scavenge or quench free radicals. On this basis, a number of antioxidants have been proposed as a treatment for reducing doxorubicin toxicity. Unfortunately, while some evidence of benefit has been seen in animal studies, at present there is inadequate supporting evidence from human trials.
- Reviewer: EBSCO CAM Review Board
- Review Date: 08/2013 -
- Update Date: 08/22/2013 -