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Reasons for Procedure
- Toxicity from immunosuppressive agents
- Injury to the liver or the pancreas
- Cholesterol problems
- Sensitization—Formation of islet cell antibodies that increase the chance of rejection for this or any future transplant. This may occur from a previous transplants, a blood transfusion, or pregnancy.
- Return of diabetes symptoms that need to be treated with resumption or increased use of self-injected insulin
- Nausea, vomiting, and abdominal pain
- Blood clots
- Worsening of kidney function
- Worsening of high blood pressure
What to Expect
Prior to Procedure
Description of Procedure
Immediately After Procedure
How Long Will It Take?
How Much Will It Hurt?
Average Hospital Stay
- You will learn how to check your blood glucose on a frequent basis.
- You and your doctor will closely control and monitor blood sugar levels with the a new insulin requirement. The dose of insulin will need to be adjusted after the transplant.
- Washing their hands
- Wearing gloves or masks
- Keeping your incisions covered
- Washing your hands often and reminding visitors and healthcare providers to do the same
- Reminding your healthcare providers to wear gloves or masks
- Not allowing others to touch your incision
Call Your Doctor
- Signs of infection, including fever and chills
- Redness, swelling, increasing pain, excessive bleeding, or discharge from the incision site
- Cough, shortness of breath, chest pain, or severe nausea or vomiting
- High or low blood glucose levels
American College of Surgeons http://www.facs.org
American Diabetes Association http://www.diabetes.org
Canadian Diabetes Association http://www.diabetes.ca
Canadian Digestive Health Foundation http://www.cdhf.ca
Bertuzzi F, Marzorati S, Secchi A. Islet cell transplantation. Curr Mol Med. 2006;6(4):369-374.
Campbell, PM, Senior, PA, Salam A, et al. High risk of sensitization after failed islet transplantation. Am J Transplant. 2007;7(10):2311-2317.
Demartines N, Schiesser M, Clavien PA. An evidence-based analysis of simultaneous pancreas-kidney and pancreas transplantation alone. Am J Transplant. 2005(11);5:2688-2697.
Diabetes mellitus type 1. EBSCO DynaMed website. Available at: http://dynamed.ebscohost.com/dynamed. Updated August 25, 2014. Accessed August 25, 2014.
Fiorina P, Secchi A. Pancreatic islet cell transplant for treatment of diabetes. Endocrinol Metab Clin N Am. 2007;36(4):999-1013.
Hogan A, Pileggi A, Ricordi C. Transplantation: current developments and future directions: the future of clinical islet transplantation as a cure for diabetes. Front Biosci. 2008;13:1192-1205.
Islet transplantation. American Diabetes Association website. Available at: http://www.diabetes.org/living-with-diabetes/treatment-and-care/transplantation/islet-transplantation.html. Updated April 7, 2014. Accessed August 25, 2014.
Leitao CB, Cure P, Tharavanij T, Baidal DA, Alejandro R. Current challenges in islet transplantation. Curr Diab Rep. 2008;8(4):324-331.
Roberson RP. Islet transplantation as a treatment for diabetes: a work in progress. N Engl J Med . 2004;350(7):694-705.
Shapiro AM, Ricordi C, Hering BJ, et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med. 2006;355(13):1318-1330.
6/3/2011 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance http://dynamed.ebscohost.com/dynamed: Mills E, Eyawo O, Lockhart I, et al. Smoking cessation reduces postoperative complications: a systematic review and meta-analysis. Am J Med. 2011;124(2):144-154.
- Reviewer: Donald Buck, MD
- Review Date: 09/2015 -
- Update Date: 01/22/2014 -