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- Having parents who are carriers of the TSD gene
- Race: Eastern European (Ashkenazi) Jewish descent
- TSD is also frequently found in French Canadian and Cajun populations
- Loss of the ability to speak
- Developmental delay and intellectual disability
- Loss of bowel control
- Sleep problems
- Movement disorder (eg, gait disturbance, muscle weakness, loss of the ability to walk)
- Slurred speech
- Psychiatric problems
- Blood test—to measure hexosaminidase A activity
Genetic Alliance http://www.geneticalliance.org/
March of Dimes Birth Defects Foundation http://www.marchofdimes.com/
National Tay-Sachs & Allied Diseases Association, Inc. http://www.ntsad.org/
About Kids Health http://www.aboutkidshealth.ca/
Caring for Kids The Canadian Paediatric Society http://www.caringforkids.cps.ca/
Filho JAF, Shapiro BE. Tay-Sachs disease. Arch Neurol . 2004; 61:1466-1468.
Matalon R, Michals-Matalon K, Schiffmann R. GM2 gangliosidoses. MedLink website. Available at: http://www.medlink.com . Accessed September 30, 2011.
National Tay-Sachs & Allied Diseases Association, Inc. website. Available at: http://www.ntsad.org .
Nelson Textbook of Pediatrics . 18th ed. WB Saunders; 2007.
Tay-Sachs disease. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/ . Updated July 20, 2011. Accessed September 30, 2011.
Tay-Sachs disease information page. National Institute of Neurological Disorders and Stroke website. Available at: http://www.ninds.nih.gov/disorders/taysachs/taysachs.htm . Accessed September 30, 2011.
- Reviewer: Kari Kassir, MD
- Review Date: 11/2012 -
- Update Date: 11/26/2012 -