(Cerebral Beriberi; Korsakoff's Amnesic Syndrome; Wernicke-Korsakoff Syndrome)
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- Long-term IV nutrition
- Markedly decreased food intake accompanied by nausea/vomiting due to chemotherapy/cancer
- Chronic disease, such as AIDS
- Genetic background
- Advanced age
- Persistent vomiting leading to malnutrition
- Conditions like cancer or procedures like obesity surgery that may lead to poor food intake or absorption of nutrients
- Difficulty with walking and balance
- Double vision
- Peripheral neuropathy
- Proper diet is key. Foods that are rich in thiamine include lentils, peas, fortified breakfast cereal, pecans, spinach, oranges, milk, and eggs.
- Do not drink alcohol or only drink in moderation.
- If you have a drinking problem, talk to your doctor right way about treatment options.
Alcoholics Anonymous http://www.aa.org
National Institute on Alcohol Abuse and Alcoholism http://www.niaaa.nih.gov
Alcoholics Anonymous Canada http://www.aacanada.com
Dietitians of Canada http://www.dietitians.ca
Gale Encyclopedia of Medicine . Gale Research; 1999.
Harper C. Thiamine deficiency and associated brain damage is still common throughout the world and prevention is simple and safe. Eur J Neurol. 2006,13:1078-1082.
Impairments of brain and behavior: the neurological effects of alcohol. Alcohol Health and Research World .1997;1:21.
Korsakoff syndrome. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed . Updated January 16, 2012. Accessed February 20, 2013.
Kuo SH, Debnam JM, Fuller GN, de Groot J. Wernicke's encephalopathy: an underrecognized and reversible cause of confusional state in cancer patients. Oncology . 2009;76(1):10-18.
Lukas RV, Piantino J, Ksiazek S, et al. MRI changes in a head and neck cancer patient with Wernicke’s Encephalopathy and visual loss. Neuro-Ophthalmology . 2011;35(5-6):272-275.
The Merck Manual of Diagnosis and Therapy. Simon and Schuster, Inc; 1999.
Thomson AD, Marshall EJ. The natural history and pathophysiology of Wernicke’s encephalopathy and Korsakoff’s psychosis. Alcohol Alcohol . 2006,41:151.
Yoon CK, Chang MH, Lee DC. Wernicke-Korsakoff syndrome associated with hyperemesis gravidarum. Korean J Ophthalmol . 2005;19(3):239-42.
- Reviewer: Rimas Lukas, MD
- Review Date: 03/2013 -
- Update Date: 03/15/2013 -