(Subacute Spongiform Encephalopathy; CJD)
- Sporadic CJD—most common type, usually affecting people aged 50 years and older
- Familial CJD—an inherited form of the disease
- Iatrogenic CJD—contracted through medical procedures, such as injections of growth hormone, receipt of corneal transplants, or dura mater implants from affected donors
- Use of cadaveric growth hormone
- Cornea transplants
- Dura mater (brain tissue) grafts
- Healthcare workers who work with brain tissues
- Blood transfusion from someone with CJD
- Memory lapses
- Difficulty concentrating
- Impaired judgment
- Difficulty with speech
- Loss of coordination
- Blurred vision
- Behavior and mood changes
- Muscle spasms
- Loss of mental and physical function
- Blood tests
- Lumbar puncture to evaluate the cerebrospinal fluid that surrounds the brain and spinal cord
- Brain biopsy
- Tonsillar biopsy
|MRI Scan of the Brain|
|Copyright © Nucleus Medical Media, Inc.|
- Prescription pain relievers
- Anticonvulsive medication for neuromuscular symptoms
Creutzfeldt-Jakob Disease Foundation, Inc. http://www.cjdfoundation.org
National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov
Health Canada http://www.hc-sc.gc.ca
Public Health Agency of Canada http://www.phac-aspc.gc.ca
Brown K, Mastrianni JA. The prion diseases. J Geriatr Psychiatry Neurol. 2010;23(4):277-298.
Creutzfeldt-Jakob disease. EBSCO DynaMed website. Available at: http://www.ebscohost.com. Updated August 28, 2014. Accessed September 17, 2014.
Creutzfeldt-Jakob disease, classic (CJD). Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov/prions/cjd/index.html. Updated December 11, 2013. Accessed September 17, 2014.
Creutzfeldt-Jakob disease fact sheet. National Institute of Neurological Disorders and Stroke website. Available at: http://www.ninds.nih.gov/disorders/cjd/detail%5Fcjd.htm. Updated May 22, 2014. Accessed September 17, 2014.
Mastrianni JA. The genetics of prion disease. Genet Med. 2010;12(4):187-195.
Patry D, Curry B, Easton D, Mastrianni JA, Hogan DB. Creutzfeld-Jakob disease (CJD) after blood product transfusion from a donor with CJD. Neurology. 1998;50(6):1872-1873.
Rinne ML, McGinnis SM, Samuels MA, Katz JT, Loscalzo J. Clinical problem-solving. A startling decline. N Engl J Med. 2012;366(9):836-842.
- Reviewer: Rimas Lukas, MD
- Review Date: 08/2015 -
- Update Date: 09/17/2014 -