Principal Proposed Uses
What Is the Scientific Evidence for Methyl Sulfonyl Methane?
1 Hucker HB, Ahmed PM, Miller EA, et al. Metabolism of dimethyl sulphoxide to dimethyl sulphone in the rat and man. Nature. 1966;209:619-620.
2 Jacob SW and Herschler R. Introductory remarks: dimethyl sulfoxide after twenty years. Ann N Y Acad Sci. 1983;411:12-17.
3 Lawrence RM. Methyl-sulfonyl-methane (MSM). A double-blind study of its use in degenerative arthritis. Unpublished correspondence.
4 Murav’ev IuV, Venikova MS, Pleskovskaia GN, et al. Effect of dimethyl sulfoxide and dimethyl sulfone on a destructive process in the joints of mice with spontaneous arthritis [in Russian]. Patol Fiziol Eksp Ter. 1991;2:37-39.
5 Childs SJ. Dimethyl sulfone (DMSO 2 ) in the treatment of interstitial cystitis. Urol Clin North Am. 1994;21:85-88.
6 Hanno PM, Wein AJ. Medical treatment of interstitial cystitis (other than rimso-50/elmiron). Urology. 1987; 29:22-26.
7 Jacob SW. The current status on the use of a new pharmacologic approach (dimethyl sulfone) for the relief of snoring. Oregon Health Sciences University. Unpublished.
8 McCabe D, O’Dwyer P, Sickle-Santanello B, et al. Polar solvents in the chemoprevention of dimethylbenzanthracene-induced rat mammary cancer. Arch Surg. 1986;121:1455-1459.
9 O'Dwyer PJ, McCabe DP, Sickle-Santanello BJ, et al. Use of polar solvents in chemoprevention of 1,2-dimethylhydrazine-induced colon cancer. Cancer. 1988;62:944-948.
10 Morton JI and Siegel BV. Effects of oral dimethyl sulfoxide and dimethyl sulfone on murine autoimmune lymphoproliferative disease. Proc Soc Exp Biol. Med 1986;183:227-230.
12 Morton JI and Siegel BV. Effects of oral dimethyl sulfoxide and dimethyl sulfone on murine autoimmune lymphoproliferative disease. Proc Soc Exp Biol Med. 1986;183:227-230.
13 Lawrence R. The effectiveness of the use of oral lignisul MSM (methylsulfonylmethane) supplementation on hair and nail health (unpublished). Available at: http://www.msm.com/msmresearch.cfm# . Accessed May 15, 2002.
14 Lawrence R, Sanchez D, Grosman M. Lignisul MSM (methylsulfonylmethane) in the treatment of acute athletic injuries (unpublished). Available at: http://www.msm.com/msmresearch.cfm# . Accessed May 14, 2002.
15 Lawrence R. Lignisul MSM (methylsulfonylmethane): A double-blind study of its use in degenerative arthritis (unpublished). Available at: http://www.msm.com/msmresearch.cfm . Accessed October 30, 2001.
16 Usha P.R., Naidu M.U.R. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clinical Drug Investigation . 2004;24:353-363.
17 Kim LS, Axelrod LJ, Howard P et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage . 2005 Nov 22. [Epub ahead of print]
18 Kim LS, Axelrod LJ, Howard P et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage . 2005 Nov 22. [Epub ahead of print]
19 Berardesca E, Cameli N, Cavallotti C, et al. Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation. J Cosmet Dermatol. 2008;7:8-14.
20 Brien S, Prescott P, Bashir N, et al. Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis. Osteoarthritis Cartilage. 2008 Apr 14.
21 Debbi EM, Agar G, Fichman G, et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011;11:50.
22 Lin A, Nguy CH, et al. Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy. 2001;123(2-3):169-177.
- Reviewer: EBSCO CAM Review Board
- Review Date: 09/2014 -
- Update Date: 09/18/2014 -