What Is Goldenseal Used for Today?
- There is no credible evidence that goldenseal increases immunity. Only one study weakly hints at an immune strengthening effect. 19
- Colds are caused by viruses and viruses don't respond to antibiotics.
- Goldenseal was never used traditionally for the common cold.
1 Hahn FE, Ciak J. Berberine. Antibiotics . 1976;3:577-584.
2 Amin AH, Subbaiah TV, Abbasi KM. Berberine sulfate: antimicrobial activity, bioassay, and mode of action. Can J Microbiol . 1969;15:1067-1076.
3 Bensky D, Gamble A, Kaptchuk TJ. Chinese Herbal Medicine: Materia Medica . Seattle, WA: Eastland Press; 1986.
4 Bergner P. The Healing Power of Echinacea, Goldenseal and Other Immune System Herbs . Rocklin, CA: Prima Publishing; 1997.
5 Pasqual MS, Lauer CP, Moyna P, Henriques JA. Genotoxicity of the isoquinoline alkaloid berberine in prokaryotic and eukaryotic organisms. Mutat Res. 1993;286:243-252.
6 Foster S. Botanical Series No. 309: Goldenseal. Austin, TX: American Botanical Council, 1991:5-6.
7 De Smet PAGM, ed. Adverse Effects of Herbal Drugs . Berlin, Germany: Springer-Verlag; 1992: 97-104.
8 Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate. 1993;63:201-208.
9 Budzinski JW, Foster BC, Vandenhoek S, et al. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine. 2000;7:273-282.
10 Bae EA, Han MJ, Kim NJ, Kim DH. Anti- Helicobacter pylori activity of herbal medicines. Biol Pharm Bull. 1998;21:990-992.
11 Kaneda Y. In vitro effects of berberine sulphate on the growth and structure of Entamoeba histolytica , Giardia lamblia , and Trichomonas vaginali S.Ann Trop Med Parasitol. 1991;85:417-425.
12 Scazzocchio F, Cometa MF, Tomassini L, et al. Antibacterial activity of Hydrastis canadensis extract and its major isolated alkaloids. Planta Med. 2001;67:561-564.
13 Soffar SA, Metwali DM, Abdel-Aziz SS, et al. Evaluation of the effect of a plant alkaloid (berberine derived from Berberis aristata ) on Trichomonas vaginalis in vitro . J Egypt Soc Parasitol. 2001;31:893-904.
14 Stermitz FR, Lorenz P, Tawara JN, et al. Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor. Proc Natl Acad Sci U S A. 2000; 97:1433-1437.
15 Hui KK, Yu JL, Chan WF, Tse E. Interaction of berberine with human platelet alpha 2 adrenoceptors. Life Sci. 1991;49:315-324.
16 Lau CW, Yao XQ, Chen ZY, et al. Cardiovascular actions of berberine. Cardiovasc Drug Rev. 200l;19:234-244.
17 Abdel-Haq H, Cometa MF, Palmery M, et al. Relaxant effects of Hydrastis canadensis L. and its major alkaloids on guinea pig isolated trachea. Pharmacol Toxicol. 2000;87:218-222.
18 Yesilada E, Kupeli E. Berberis crataegina DC. root exhibits potent anti-inflammatory, analgesic and febrifuge effects in mice and rats. J Ethnopharmacol . 2002;79:237-248.
19 Rehman J, Dillow JM, Carter SM, et al. Increased production of antigen-specific immunoglobulins G and M following in vivo treatment with the medicinal plants Echinacea angustifolia and Hydrastis canadensis . Immunol Lett. 1999;68:391-395.
20 Inbaraj JJ, Kukielczak BM, Bilski P, et al. Photochemistry and photocytotoxicity of alkaloids from Goldenseal ( Hydrastis canadensis L. ). Chem Res Toxicol. 2001;14:1529-1534.
21 Kong W, Wei J, Abidi P, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med . 2004 Nov 07 [Epub ahead of print]
22 Wu X, Li Q, Xin H et al. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol . 2005 Aug 26 [Epub ahead of print].
23 Gurley BJ, Swain A, Hubbard MA, et al. Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: Effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and echinacea. Mol Nutr Food Res. 2008 Jan 23.
24 Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab. 2008 Apr 8.
25 Yu H, Kim KJ, Cha JD, et al. Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus. J Med Food. 2005 Winter;8(4):454-61.
26 Cecil CE, Davis JM, Cech NB, Laster SM. Inhibition of H1N1 influenza A virus growth and induction of inflammatory mediators by the isoquinoline alkaloid berberine and extracts of goldenseal (Hydrastis canadensis). Int mmunopharmacol.2011 Nov;11(11):1706-14
27 Zuo GY, Li Y, Han J, et al. Antibacterial and synergy of berberines with antibacterial agents against clinical multi-drug resistant isolates of methicillin-resistant Staphylococcus aureus (MRSA). Molecules. 2012 Aug 29;17(9):10322-30.
- Reviewer: EBSCO CAM Review Board
- Review Date: 09/2014 -
- Update Date: 02/26/2015 -